简历介绍

刘哲益，男，博士，副研究员，硕士生导师。2011年毕业于浙江工业大学，获理学学士学位；2017年毕业于中国科学院大连化学物理研究所，获得分析专业博士学位。毕业后留所工作至今，2021年晋升为副研究员。研究方向致力于发展先进光源-生物质谱创新仪器装置和方法，基于非变性质谱技术和紫外激光解离质谱技术，探测蛋白质及其复合物的序列、修饰和相互作用。以第一作者/通讯作者（包括共同）身份发表SCI论文20余篇，包括Nat Protoc、J Am Chem Soc、ACS Nano、Chem Sci、Cell Chem Biol、Anal Chem等期刊，论文引用1800余次，授权专利5项。

代表论著

1.     Yuanzhi Xie#; Zheyi Liu#; Huiwen Qin; Heng Zhao; Weiqing Zhang; Chunlei Xiao; Xian Wang*; Xueming Yang; Fangjun Wang*, Ultraviolet Photodissociation Mass Spectrometry Captures the Acyl Chain Length-Dependent Conformation Dynamics of Acyl Carrier Protein, J Am Chem Soc, 2025, 147(20): 16760-16765.

2.     Pan Luo#; Zheyi Liu#; Can Lai; Zhixiong Jin; Mengdie Wang; Heng Zhao; Yu Liu; Weiqing Zhang; Xingan Wang; Chunlei Xiao; Xueming Yang; Fangjun Wang*, Time-Resolved Ultraviolet Photodissociation Mass Spectrometry Probes the Mutation-Induced Alterations in Protein Stability and Unfolding Dynamics, J Am Chem Soc, 2024, 146(13): 8832-8838.

3.     Zheyi Liu#; Shirui Yang#; Lingqiang Zhou#; Min He; Yu Bai; Shan Zhao; Fangjun Wang*, Structural characterization of protein-material interfacial interactions using lysine reactivity profiling-mass spectrometry, Nat Protoc, 2023, 18(8): 2600-2623.

4.     Zheyi Liu#; Xiong Chen#; Shirui Yang; Ruijun Tian*; Fangjun Wang*, Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization, Curr Opin Chem Biol, 2023, 74: 102305.

5.     Yu Bai#; Zheyi Liu#; Yuanqing Li#; Heng Zhao; Can Lai; Shan Zhao; Kaixian Chen; Cheng Luo*; Xueming Yang; Fangjun Wang*, Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation, J Am Chem Soc, 2023, 145(21): 11477-11481.